Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN19 | JPN19B | Japan | 2000 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC | 14 |
| 2 | AZT+ 3TC+ NFV | 77 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88S | L10F | G16E, K20I, E35D, M36I, R41K, L63T, I64V, H69K, L89M, I93L |
| >JPN19B| codons 1-99 PQITLWQRPFVTIKIEGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QITVEICGKKAIGTVLVGPTPVNIIGRSMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | E6D, K11T, V21VI, V35T, T39K, K43E, K122E, D123N, S162C, P170PS, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, E224ED, K238R, Q242QP, I244IV |
| >JPN19B| codons 1-244 PISPIDTVPVTLKPGMDGPKIKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILESFRIKNPEMVI YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKDPPFLWMGYELHPDRWT VPPV |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |