<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JPN34 JPN34 Japan 2000 HIV1 CRF01_AE Plasma None

Treatment History
Order Regimen Weeks
1 IDV+ AZT+ 3TC 12
2 AZT+ 3TC+ SQV 64

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54IV L33LF, N83ND L10LI, I13V, I15V, E35D, M36I, R41K, L63P, H69K, L89M  
>JPN34| codons 1-99
PQITLWQRPIVTVKVGGQLKEALLDTGADDTVFEDINLPGKWKPKMIVGIGGFVKVRQYD
QIPIEICGKKAIGTVLVGPTPVDIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, M184V       E6D, V8I, K11T, V21I, V35T, T39K, K43E, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, Q207A, R211S, K238R, V245E  
>JPN34| codons 1-253
PISPIDTIPVTLKPGMDGPKIKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEMVI
YQYVDDLYVGSDLEIGQHRTKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDRWT
VQPIELPEKDSWT

References
Author Title Citation
Ariyoshi, K Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. JAIDS, 2003
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005