Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN31 | JPN31 | Japan | 2000 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ SQV | 29 |
| 2 | AZT+ 3TC | 21 |
| 3 | AZT+ 3TC+ NFV | 103 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L33LI, N83D, L89IV | L10LI, I13V, K20KT, A22AV, E35D, M36I, R41K, I62V, H69K |
| >JPN31| codons 1-99 PQITLWQRPIVTVKIGGQLTEVLLDTGADDTVIEDINLPGKWKPKMIGGIGGFIKVRQYD QVLIEICGKKAIGTVLVGPTPVDIIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | E6ED, V35T, T39K, K43E, K122E, D123S, I135T, K173I, Q174K, D177E, I178M, Q207A, R211S, F214FL, K238R, V245T |
| >JPN31| codons 1-248 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEMVI YQYVDDLYVGSDLEIGQHRTKIEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDRWT VQPITLPE |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |