Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN15 | JPN15 | Japan | 1999 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 25 |
| 2 | DDC+ AZT | 42 |
| 3 | AZT+ DDC+ NFV | 40 |
| 4 | D4T+ 3TC+ IDV | 73 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | L10F, L33I | I13V, K20R, E35D, M36I, R41K, I64V, H69K, L89M |
| >JPN15| codons 1-99 PQITLWQRPFVTVKIGGQLREALLDTGADDTVIEDINLPGKWKPKMIGGIGGFVKVRQYD QILVEICGKKAIGTVLVGPTPVNIIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | E6N, K11T, V35T, T39K, K43E, V60I, V118VI, K122E, D123S, I135T, K173IV, Q174K, D177E, G196GE, Q207A, R211S, K238R, V245E |
| >JPN15| codons 1-252 PISPINTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRVKNPEIVI YQYVDDLYVGSDLEIEQHRTKIEELRAHLWSWGFYTPDNKHQKEPPFLWMGYELHPDRWT VQPIELPEKDSW |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |