<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JPN13 JPN13B Japan 1999 HIV1 CRF01_AE Plasma None

Treatment History
Order Regimen Weeks
1 AZT 43
2 AZT+ DDI 161

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, T215F K219Q     V35T, T39K, K43E, V60I, S105ST, K122E, D123S, K173M, Q174K, D177E, V179I, G196E, T200I, E204Q, Q207A, R211S, L228H, K238R  
>JPN13B| codons 16-240
MDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPIFAIKKKNSDRWRKLV
DFRELNKRTQDFWEVQLGIPHPAGLKKKKTVTVLDVGDAYFSVPLDESFRKYTAFTIPSI
NNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRMKNPEIIIYQYMDDLYVGSDLEI
EQHRIKIEQLRAHLLSWGFFTPDQKHQKEPPFHWMGYELHPDRWT

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, M36I, R41K, H69K, L89M  
>JPN13B| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Ariyoshi, K Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. JAIDS, 2003
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005