<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JPN12 JPN12B Japan 1999 HIV1 CRF01_AE Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ DDI 22
2 AZT+ 3TC 61
3 D4T+ 3TC+ SQV 92

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  Q58E I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89M  
>JPN12B| codons 1-99
PQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVREYD
QILIEICGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, T215F V75M, K219Q     K20R, V35T, T39K, K43E, V60I, K64H, T69N, D121H, K122E, D123S, S162SDGN, I167V, K173I, Q174K, D177E, T200I, Q207A, R211S, D218E, L228H, K238R  
>JPN12B| codons 16-240
MDGPRVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPIFAIHKKNSNRWRKLM
DFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLHESFRKYTAFTIPSI
NNETPGIRYQYNVLPQGWKGSPAIFQNSMTKVLEPFRIKNPEIVIYQYVDDLYVGSDLEI
GQHRIKIEELRAHLLSWGFFTPEQKHQKEPPFHWMGYELHPDRWT

References
Author Title Citation
Ariyoshi, K Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. JAIDS, 2003
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005