Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN12 | JPN12B | Japan | 1999 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | 22 |
| 2 | AZT+ 3TC | 61 |
| 3 | D4T+ 3TC+ SQV | 92 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q58E | I13V, K20I, E35D, M36I, R41K, H69K, V82I, L89M |
| >JPN12B| codons 1-99 PQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVREYD QILIEICGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, T215F | K219Q | K20R, V35T, T39K, K43E, V60I, K64H, T69N, D121H, K122E, D123S, S162SDGN, I167V, K173I, Q174K, D177E, T200I, Q207A, R211S, D218E, L228H, K238R |
| >JPN12B| codons 16-240 MDGPRVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPIFAIHKKNSNRWRKLM DFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLHESFRKYTAFTIPSI NNETPGIRYQYNVLPQGWKGSPAIFQNSMTKVLEPFRIKNPEIVIYQYVDDLYVGSDLEI GQHRIKIEELRAHLLSWGFFTPEQKHQKEPPFHWMGYELHPDRWT |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |