<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JPN45 JPN45B Japan 2002 HIV1 CRF01_AE Plasma None

Treatment History
Order Regimen Weeks
1 IDV+ AZT 64
2 DDI+ D4T+ EFV 114
3 D4T 33
4 APV+ D4T+ 3TC+ LPV 4

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, L210W, T215Y D67S Y188L   E6D, K11T, V35T, T39K, K43E, S68T, T69S, W88S, V106L, V118I, K122E, D123S, I135V, S162C, K173I, Q174K, D177E, G196E, Q207T, R211N, K238R, P243H, V245E  
>JPN45B| codons 1-266
PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPV
FAIKKKSTSKWRKVVDFRELNKRTQDFSEVQLGIPHPAGLKKKKSLTVLDVGDAYFSIPL
DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRIKNPEIVI
YQYMDDLLVGSDLEIEQHRTKIEELRTHLWNWGFYTPDKKHQKEPPFLWMGYELHPDRWT
VQHIELPEKDSWTVNDIQKLVGKLNW

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
N88S L10F, L89V I13V, K20T, E35D, M36I, P39PS, R41K, L63P, H69K, A71T  
>JPN45B| codons 1-99
PQITLWQRPFVTVKIGGQLTEALLDTGADDTVLEDINLSGKWKPKMIGGIGGFIKVRQYD
QIPIEICGKKTIGTVLVGPTPVNIIGRSVLTQIGCTLNF

References
Author Title Citation
Ariyoshi, K Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. JAIDS, 2003
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005