Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN45 | JPN45B | Japan | 2002 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV+ AZT | 64 |
| 2 | DDI+ D4T+ EFV | 114 |
| 3 | D4T | 33 |
| 4 | APV+ D4T+ 3TC+ LPV | 4 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88S | L10F, L89V | I13V, K20T, E35D, M36I, P39PS, R41K, L63P, H69K, A71T |
| >JPN45B| codons 1-99 PQITLWQRPFVTVKIGGQLTEALLDTGADDTVLEDINLSGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKTIGTVLVGPTPVNIIGRSVLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | D67S | Y188L | E6D, K11T, V35T, T39K, K43E, S68T, T69S, W88S, V106L, V118I, K122E, D123S, I135V, S162C, K173I, Q174K, D177E, G196E, Q207T, R211N, K238R, P243H, V245E |
| >JPN45B| codons 1-266 PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPV FAIKKKSTSKWRKVVDFRELNKRTQDFSEVQLGIPHPAGLKKKKSLTVLDVGDAYFSIPL DESFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRIKNPEIVI YQYMDDLLVGSDLEIEQHRTKIEELRTHLWNWGFYTPDKKHQKEPPFLWMGYELHPDRWT VQHIELPEKDSWTVNDIQKLVGKLNW |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |