Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN43 | JPN43B | Japan | 2002 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC+ AZT | 202 |
| 2 | D4T+ 3TC+ NFV | 67 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | D67G, K219E | E6D, K11T, V35T, T39K, M41X, V60I, S68G, K122E, D123S, I135IT, K173T, Q174K, D177E, I178M, V179VI, Q207A, R211S, V245K |
| >JPN43B| codons 1-266 PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKEXEKEGKISKIGPENPYNTPI FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEMII YQYVDDLYVGSDLEIGQHRTKIEELRAHLLSWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, L90LM | L10LF | I13V, I15V, K20T, E35D, M36I, R41K, H69K, A71AT, T74TS, L89X, I93IL |
| >JPN43B| codons 1-99 PQITLWQRPFVTVKVGGQLTEALLDTGADDTVLEDINLPGKWKPKIIGGIGGFIKVRQYD QILIEICGKKTIGSVLVGPTPVNIIGRNXMTQLGCTLNF |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |