Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| JPN42 | JPN42B | Japan | 2001 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ SQV | 120 |
| 2 | None | 10 |
| 3 | ABC+ EFV+ RTV+ APV | 44 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, M184V, L210W, T215Y | K219Q | E6D, K11T, V35T, T39K, K43E, V60I, V118I, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, Q207A, R211S, D218E, V245K |
| >JPN42B| codons 1-250 PISPIDTVPVTLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEMII YQYVDDLYVGSDLEIGQHRTKIEELRAHLWSWGFYTPEQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, V82VF, L90LM | L33I, I84IL | L10LV, I13V, G16E, K20KI, E35D, M36I, N37ND, R41K, H69K, T74TS, L89IM, Q92K |
| >JPN42B| codons 1-99 PQITLWQRPVVTVKIEGQLIEALLDTGADDTVIEDIDLPGKWKPKMIGGIGGFVKVRQYD QILIEICGKKAIGSVLVGPTPFNLIGRNIMTKIGCTLNF |
References
| Author | Title | Citation |
| Ariyoshi, K | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | JAIDS, 2003 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |