<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
3PoBV 3PoBV46 U.S. 1994 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI+IDV 46

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A   L10I, I62V, L63Q, I93L  
>3PoBV46| 1 | codons 1-99 | clone 1
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTILVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 2 | codons 1-99 | clone 2
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 3 | codons 1-99 | clone 3
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 4 | codons 1-99 | clone 4
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 5 | codons 1-99 | clone 5
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 6 | codons 1-99 | clone 6
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 8 | codons 1-99 | clone 8
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 11 | codons 1-99 | clone 11
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 12 | codons 1-99 | clone 12
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 13 | codons 1-99 | clone 13
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIETCGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 14 | codons 1-99 | clone 14
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| 21 | codons 1-99 | clone 21
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPRRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV46| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Zhang, Y-M Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. J Virol, 1997
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005