Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 3PoBV | 3PoBV75 | U.S. | 1995 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI+IDV | 75 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I | L10I, I62V, L63Q, A71V, I93L |
| >3PoBV75| 22 | codons 1-99 | clone 22 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QAQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGGTLNF >3PoBV75| 23 | codons 1-99 | clone 23 PQITLWRLPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV75| 24 | codons 1-99 | clone 24 PQITLWRRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV75| 25 | codons 1-99 | clone 25 PLITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGFTLNF >3PoBV75| 26 | codons 1-99 | clone 26 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGFTLNF >3PoBV75| 27 | codons 1-99 | clone 27 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGFTLNF >3PoBV75| 28 | codons 1-99 | clone 28 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV75| 31 | codons 1-99 | clone 31 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV75| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Zhang, Y-M | Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. | J Virol, 1997 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |