<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
3PoBV 3PoBV75 U.S. 1995 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI+IDV 75

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L24I L10I, I62V, L63Q, A71V, I93L  
>3PoBV75| 22 | codons 1-99 | clone 22
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QAQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGGTLNF
>3PoBV75| 23 | codons 1-99 | clone 23
PQITLWRLPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV75| 24 | codons 1-99 | clone 24
PQITLWRRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV75| 25 | codons 1-99 | clone 25
PLITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD
QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGFTLNF
>3PoBV75| 26 | codons 1-99 | clone 26
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD
QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGFTLNF
>3PoBV75| 27 | codons 1-99 | clone 27
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGFTLNF
>3PoBV75| 28 | codons 1-99 | clone 28
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD
QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV75| 31 | codons 1-99 | clone 31
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD
QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV75| codons 1-99
PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD
QVQIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Zhang, Y-M Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. J Virol, 1997
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005