Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ALD-pt17 | ALD-pt17 | Australia | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NNRTI|NRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K103N, Y181C | V21I, E28K, K32E, T39K, K43E, E44D, V60I, V111I, V118I, I142V, S162C, I178L, V179I, G196E, E203D, E204Q, H208Y, R211K, H221Y, V245T, A288S, I293V, E297K, E312EQ |
| >ALD-pt17| codons 1-320 PISPIETVPVKLKPGMDGPKIKQWPLTKEKIEALVEICKELEEDGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDIGDAYFSIPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLII CQYMDDLYVGSDLEIEQHRTKIDQLRQYLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTKEAE LELAENREILKQPVHGVYYD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73GS | L10I, K20IM, E35D, M36I, I62IV, L63P, A71AV, I93IL |
| >ALD-pt17| codons 1-99 PQITLWQRPIVTIKIGGQLMEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKVISTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Dunne, AL | Comparison of genotyping and phenotyping methods for determining susceptibility of HIV-1 to antiretroviral drugs. | AIDS, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |