<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
3PoBV 3PoBV53 U.S. 1994 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI+IDV 53

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A   L10I, I62V, L63Q, I93L G52S, K55Q
>3PoBV53| 1 | codons 1-99 | clone 1
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV53| 4 | codons 1-99 | clone 4
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV53| 5 | codons 1-99 | clone 5
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV53| 6 | codons 1-99 | clone 6
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV53| 7 | codons 1-99 | clone 7
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGSFVQVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV53| 10 | codons 1-99 | clone 10
PQITLWQRPIVTIKIGGQLKEALLDTGADDIVLEEMNLPGRWKPKLIGGIGSFVQVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV53| 14 | codons 1-99 | clone 14
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGSFVQVRQYD
QVQIEICGHKAIGTVLVGPTSANIIGRNLLTQLGCTLNF
>3PoBV53| 18 | codons 1-99 | clone 18
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV53| 19 | codons 1-99 | clone 19
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QVLIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV53| 20 | codons 1-99 | clone 20
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVIVRQYD
QVLIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF
>3PoBV53| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGSFVQVRQYD
QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Zhang, Y-M Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. J Virol, 1997
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005