Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 3PoBV | 3PoBV53 | U.S. | 1994 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI+IDV | 53 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10I, K55Q, I62V, L63Q, I93L | G52S |
| >3PoBV53| 1 | codons 1-99 | clone 1 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV53| 4 | codons 1-99 | clone 4 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV53| 5 | codons 1-99 | clone 5 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV53| 6 | codons 1-99 | clone 6 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV53| 7 | codons 1-99 | clone 7 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGSFVQVRQYD QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV53| 10 | codons 1-99 | clone 10 PQITLWQRPIVTIKIGGQLKEALLDTGADDIVLEEMNLPGRWKPKLIGGIGSFVQVRQYD QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV53| 14 | codons 1-99 | clone 14 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGSFVQVRQYD QVQIEICGHKAIGTVLVGPTSANIIGRNLLTQLGCTLNF >3PoBV53| 18 | codons 1-99 | clone 18 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV53| 19 | codons 1-99 | clone 19 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QVLIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV53| 20 | codons 1-99 | clone 20 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVIVRQYD QVLIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >3PoBV53| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGSFVQVRQYD QVQIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Zhang, Y-M | Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. | J Virol, 1997 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |