Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ALD-pt7 | ALD-pt7 | Australia | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NNRTI|NRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, Q151QKLM, T215F | K219Q | Y188L | V35T, T39K, K43E, V60I, T69N, K102Q, L109LI, K122E, D123N, K166R, G196E, I202V, L210F, A272P, K277R, E297K |
| >ALD-pt7| codons 1-320 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKELEEEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVIDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYMDDLLVGSDLEIEQHRTKVEELRQHLFRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12TA, I13IV, L19I, N37NHPT, R41K, I62IV, L63P |
| >ALD-pt7| codons 1-99 PQITLWQRPLVAVKIGGQIKEALLDTGADDTVLEEMTLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Dunne, AL | Comparison of genotyping and phenotyping methods for determining susceptibility of HIV-1 to antiretroviral drugs. | AIDS, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |