Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 3PoBV | 3PoBV14 | U.S. | 1993 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI+IDV | 14 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q7K, L10I, R41K, I85V, I93L | A28V |
| >3PoBV14| 2 | codons 1-99 | clone 2 PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILMEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF >3PoBV14| 9 | codons 1-99 | clone 9 PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF >3PoBV14| 12 | codons 1-99 | clone 12 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEKMNLPGRWKPKMIGGIGGFIKVRQYD QIQIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >3PoBV14| 17 | codons 1-99 | clone 17 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEKMNLPGRWKPKMIGGIGGFIKVRQYD QIQIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >3PoBV14| 33 | codons 1-99 | clone 33 PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTSNF >3PoBV14| 36 | codons 1-99 | clone 36 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLDCTLNF >3PoBV14| 37 | codons 1-99 | clone 37 PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF >3PoBV14| 40 | codons 1-99 | clone 40 PQITLWKRPIVTIKIGGQLKEALLDTGVDDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF >3PoBV14| 51 | codons 1-99 | clone 51 PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF >3PoBV14| 53 | codons 1-99 | clone 53 PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF >3PoBV14| 54 | codons 1-99 | clone 54 PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF >3PoBV14| 59 | codons 1-99 | clone 59 PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF >3PoBV14| 60 | codons 1-99 | clone 60 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEKMNLPGRWKPKMIGGIGGFIKVRQYD QIQIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >3PoBV14| 70 | codons 1-99 | clone 70 PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF >3PoBV14| codons 1-99 PQITLWKRPIVTIKIGGQLKEALLDTGVDDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIVGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Zhang, Y-M | Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. | J Virol, 1997 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |