<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
8LaBV 8LaBV72 U.S. 1995 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI+IDV 72

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I54V, V82A   L10V, K20M, M36I, I62V, L63P, I64V, E65D  
>8LaBV72| 25 | codons 1-99 | clone 25
PQITLWQRPIVTIKIGGQLMEALLDTGADDTVLEEINLPGRWTPKMIVGIGGFVKVRQYD
QVPVEICGQKAIGTVLVGPTPANIIGRNLLTQIGCTLNF
>8LaBV72| 26 | codons 1-99 | clone 26
PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYD
QVPVDICGHKAIGTVLVGPIPANIIGRNLLTQIGCTLNF
>8LaBV72| 27 | codons 1-99 | clone 27
PQITLWQRPVVTVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYD
QVPVEICGHKAIGTVLIGPTPVNIIGRNLMTKLGCTLNF
>8LaBV72| 28 | codons 1-99 | clone 28
PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD
QVPVEICGHKAIGTVLIGPTPVNIIGRNLMTKLGCTLNF
>8LaBV72| 30 | codons 1-99 | clone 30
PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLKEMNLPGRWKPKIIGGIGGFIKVRQYD
QVPVEICGHKAIGTVLIGPTPVNIIGRNLMTKLGCTLNF
>8LaBV72| 31 | codons 1-99 | clone 31
PQITLWQRPVVTIKIGGQLMEALLDTGADETVLEEINLPGRWKPKMIGGIGGFVKVRQYD
QVPVDICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF
>8LaBV72| 32 | codons 1-99 | clone 32
PQITLWQRPIVTIKIGGQLMKALLDTGADDTVLEEINLPGRWIPKMIVGIGGFVKVRQYD
QVPVGICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF
>8LaBV72| 33 | codons 1-99 | clone 33
PQITLWQRPVVTIKIGGQLMEALLDTGANDTVLEEINLPGRWKPKMIGGIGGFVKVRQYD
QVPVDICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF
>8LaBV72| 34 | codons 1-99 | clone 34
PQITLWQRPVVTIKIGGQLMEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYD
QVPVDICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF
>8LaBV72| 35 | codons 1-99 | clone 35
PQITLWQRPIVTVRIGGQLMKALLDTGADDTVLEEINLPGRWIPKMIVGIGGFVKVRQYD
QVPVDICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF
>8LaBV72| 36 | codons 1-99 | clone 36
PQITLWQRPVVTVKIGGQLMEALLDTGADDTVLEEINLPGRWTPKMIVGIGGFVKVRQYD
QVPVDICGQKAIGTVLVGPTPANIIGRNLLTQIGCTLNF
>8LaBV72| codons 1-99
PQITLWQRPVVTIKIGGQLMEALLDTGADDTVLEEINLPGRWKPKIIVGIGGFVKVRQYD
QVPVDICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF

References
Author Title Citation
Zhang, Y-M Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. J Virol, 1997
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005