Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 8LaBV | 8LaBV35 | U.S. | 1994 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI+IDV | 35 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, V82A, L90M | L10I, I13V, K20M, M36I, L63P, I64V, H69Q |
| >8LaBV35| 37 | codons 1-99 | clone 37 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWEPKIIGGIGGFIKVRQYD QVPVDICGHKAIGTVLIGPTPVNIIGRNLMTKLGCTLNF >8LaBV35| 39 | codons 1-99 | clone 39 PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKMIVGIGGFIKVRQYD QIPVEICGQKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >8LaBV35| 40 | codons 1-99 | clone 40 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFVKVRQYD QVPVDICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >8LaBV35| 42 | codons 1-99 | clone 42 PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKMIVGIGGFIKVRQYD QIPVEICGQKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >8LaBV35| 43 | codons 1-99 | clone 43 PQITLWQRPVVTVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKMIVGIGGFIKVRQYD QVPVDICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >8LaBV35| 44 | codons 1-99 | clone 44 PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLEEITLPGRWKPKMIVGIGGFIKVRQYD QIPVEICGQKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >8LaBV35| 46 | codons 1-99 | clone 46 PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKMIVGIGGFIKVRQYD QIPVEICGQKAIGTVLVGPTPANIIGRNLLTQIGCTLNF >8LaBV35| 47 | codons 1-99 | clone 47 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QVPVDICGHKAIGTVLIGPTPVNIIGRNLMTKLGCTLNF >8LaBV35| 48 | codons 1-99 | clone 48 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QVPVDICGHKAIGTVLIGPTPVNIIGRNLMTKLGCTLNF >8LaBV35| codons 1-99 PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKIIVGIGGFIKVRQYD QIPVEICGQKAIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Zhang, Y-M | Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. | J Virol, 1997 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |