Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| UK2095 | UK2095 | U.K. | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | SQV | 52 |
| 2 | DDI+ AZT+ SQV | 12 |
| 3 | IDV+ 3TC+ SQV | 78 |
| 4 | NFV+ DDI+ D4T | 47 |
| 5 | RTV+ NVP+ D4T+ SQV | 30 |
| 6 | LPV+ ABC+ D4T | 98 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, M36I, H69K, L89M, I93L |
| >UK2095| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70KR, T215TFIS | K219E | G190GA | K11KR, V35T, T39E, S48T, V60I, K122E, D123S, K173A, D177E, T200A, Q207G, R211K |
| >UK2095| codons 1-234 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI YQYMDDLYVASDLEIGQHRAKIEELRGHLLKWGFSTPDEKHQKEPPFLWMGYEL |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |