<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
6HeBV 6HeBV71 U.S. 1995 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI+IDV 71

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I L10I, I15V, K20R, M36I, L63P, K70Q, L89M  
>6HeBV71| 13 | codons 1-99 | clone 13
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF
>6HeBV71| 14 | codons 1-99 | clone 14
PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD
QIPVEICGHQVMGTVLVGPTPANIIGRNLMTHIGCTLNF
>6HeBV71| 15 | codons 1-99 | clone 15
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLKEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF
>6HeBV71| 16 | codons 1-99 | clone 16
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNLMTQIGCTLNF
>6HeBV71| 17 | codons 1-99 | clone 17
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF
>6HeBV71| 18 | codons 1-99 | clone 18
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF
>6HeBV71| 19 | codons 1-99 | clone 19
PQITLWQRPIVTIKVGGQLREALIGTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF
>6HeBV71| 20 | codons 1-99 | clone 20
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPAPANIIGRNMLTQIGCTLNF
>6HeBV71| 21 | codons 1-99 | clone 21
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF
>6HeBV71| 22 | codons 1-99 | clone 22
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF
>6HeBV71| 23 | codons 1-99 | clone 23
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF
>6HeBV71| 24 | codons 1-99 | clone 24
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF
>6HeBV71| codons 1-99
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF

References
Author Title Citation
Zhang, Y-M Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. J Virol, 1997
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005