Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 6HeBV | 6HeBV71 | U.S. | 1995 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI+IDV | 71 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I | L10I, I15V, K20R, M36I, L63P, K70Q, L89M |
| >6HeBV71| 13 | codons 1-99 | clone 13 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF >6HeBV71| 14 | codons 1-99 | clone 14 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVRQYD QIPVEICGHQVMGTVLVGPTPANIIGRNLMTHIGCTLNF >6HeBV71| 15 | codons 1-99 | clone 15 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLKEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF >6HeBV71| 16 | codons 1-99 | clone 16 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNLMTQIGCTLNF >6HeBV71| 17 | codons 1-99 | clone 17 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF >6HeBV71| 18 | codons 1-99 | clone 18 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF >6HeBV71| 19 | codons 1-99 | clone 19 PQITLWQRPIVTIKVGGQLREALIGTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF >6HeBV71| 20 | codons 1-99 | clone 20 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPAPANIIGRNMLTQIGCTLNF >6HeBV71| 21 | codons 1-99 | clone 21 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF >6HeBV71| 22 | codons 1-99 | clone 22 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF >6HeBV71| 23 | codons 1-99 | clone 23 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF >6HeBV71| 24 | codons 1-99 | clone 24 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF >6HeBV71| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEICGHQAIGTVLVGPTPANIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Zhang, Y-M | Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. | J Virol, 1997 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |