Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| UK1447b | UK1447b | U.K. | 2002 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC+ IDV | 25 |
| 2 | AZT+ NFV+ 3TC | 13 |
| 3 | NFV+ AZT+ ABC+ EFV | 43 |
| 4 | DDI+ RTV+ SQV | 65 |
| 5 | 3TC+ APV+ LPV+ RTV | 29 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K219R | K103NS | P225H | V35T, T39E, S48T, V118VI, K122E, D123S, I135L, K173T, Q174K, T200A, Q207E, R211K, L228HR |
| >UK1447b| codons 1-236 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFYTPDRKHQKEHPFHWMGYELHP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L10F, L23I, K43T | I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93L |
| >UK1447b| codons 1-99 PQITLWQRPFVTIKVGGQLREAILDTGADDTVLEDINLPGKWTPKIIGGVGGFVKVRQYD QVVIEICGKKVIGSVLVGPTPANIIGRNIMTQLGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |