<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
UK1988 UK1988 U.K. 2002 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 EFV+ DDI+ D4T NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74LV   K101KE, K103N, V106VM, G190GRS   V35T, E36A, T39E, S48E, K122E, D123NS, E169K, K173E, D177E, T200A, E203EK  
>UK1988| codons 1-235
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKIEKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSMTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPEIVI
YQYMDDLYVSSDLEIGQHRAKIKELRQHLLRWGFTTPDKKHQKEPPFLWMGYELH

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, E35D, R41K, K45R, I62V, L63T, I64L, H69K, A71T, V77VI, I93L  
>UK1988| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEDMNLPGKWKPRMIGGIGGFIKVRQYD
QVTLEICGKKTIGTVLIGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005