<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
UK1972 UK1972 U.K. 2001 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ DDI NA
2 NVP+ D4T+ 3TC 211

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    E35D, M36I, R41K, L63Q, I64V, E65D  
>UK1972| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIQVDICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, T215Y   G190A   K32I, L34I, V35T, T39A, K49R, K104KR, S117A, S162CY, S163ST, D177E, I178F, T200R, Q207E, H208Y, R211K, W212R, H221Y  
>UK1972| codons 1-230
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIIAITEICAELEKEGKISRIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFAVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYTMTKILEPFRKQNPEFVI
YQYVDDLYVASDLEIGQHRRKIEELREYLLKRGFYTPDKKYQKEPPFLWM

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005