<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
UK1978 UK1978 U.K. 2002 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ DDI+ EFV NA
2 NVP+ AZT+ 3TC NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K103N   V35T, M41I, V60I, D121H, K122E, I135T, T139R, I142V, K173L, Q174K, D177E, I178L, V179I, I202V, Q207E, R211S  
>UK1978| codons 1-232
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEIEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
HEDFRKYTAFTIPSTNNERPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRLKNPELII
YQYVDDLYVGSDLEIGQHRTKVEELREHLLSWGFTTPDKKHQKEPPFLWMGY

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, E35D, M36I, R41K, L63V, H69K, L89M  
>UK1978| codons 1-99
PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005