<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
UK1386b UK1386b U.K. 2002 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 NVP+ 3TC+ D4T 48
2 ABC+ AZT+ DDI 62

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115F, Q151M, M184V A62AV, V75I, F77L, F116Y Y181I   V8I, K20R, I31L, V35T, T39E, S48T, K49R, S68G, T69TI, K122E, D123G, K173A, D177G, T200A, Q207E, R211K, F214L  
>UK1386b| codons 1-233
PISPIETIPVKLKPGMDGPRVKQWPLTEEKLKALTEICEEMEKEGKITRIGPENPYNTPV
FVIKRKDGIKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFYSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRAQNPGIVI
IQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, M36I, R41K, H69K, T74S, L89M, I93L  
>UK1386b| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005