<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12ZALS115 12ZALS115 South Africa 2012 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC|D4T|EFV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67DN, K70R, M184V K219Q V106M V179D, F227L P4S, V35T, T39E, S48T, V60VI, K122E, D123N, I135IT, K173A, Q174R, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, E291D, Q334N, G335D  
>12ZALS115| codons 1-345
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRARNPEIDI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDQKHQKEPPLLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L19V, K20R, M36I, R41K, L63T, H69K, I93L  
>12ZALS115| codons 1-99
PQITLWQRPLVTIKIGGQVREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QITIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Skhosana, L High Prevalence of the K65R Mutation in HIV-1 Subtype C Infected Patients Failing Tenofovir-Based First-Line Regimens in South Africa. PLoS ONE, 2015