Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 5MuBV | 5MuBV59 | U.S. | 1995 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI+IDV | 59 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I | K14R, R41K, K55R, A71V, I93L |
| >5MuBV59| 10 | codons 1-99 | clone 10 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKSKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >5MuBV59| 11 | codons 1-99 | clone 11 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPEKWKPKLIGGIGGFVQVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF >5MuBV59| 12 | codons 1-99 | clone 12 PQITLWQRPLVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >5MuBV59| 13 | codons 1-99 | clone 13 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGK*KPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF >5MuBV59| 14 | codons 1-99 | clone 14 PQITLWQRPLVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVRQYD QIPIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF >5MuBV59| 16 | codons 1-99 | clone 16 PQITLWQRPIVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >5MuBV59| 45 | codons 1-99 | clone 45 PQITLWQRPLVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >5MuBV59| 47 | codons 1-99 | clone 47 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >5MuBV59| 49 | codons 1-99 | clone 49 PQITLWQRPIVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >5MuBV59| 50 | codons 1-99 | clone 50 PQITLWQRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF >5MuBV59| codons 1-99 PQITLWQRPLVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVRQYD QILIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Zhang, Y-M | Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its gag substrate cleavage sites. | J Virol, 1997 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |