<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PW_56 PW_56 Uganda 1999 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ 3TC+ SQV 23
2 D4T+ 3TC+ IDV 38

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  L89MV I13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, T74TS  
>PW_56| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QVLIEICGKKAIGSVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184MV       V35T, T39K, K49R, I50IV, K122E, D123S, A158S, K173S, N175H, T200A, Q207A, R211S, V245T, A272P, K277R, K281KR, T286A, E291D, V292I, I293V, P294T, E312DG, I326V, A327AV, G335D, A355AG, M357K, R358G, G359S, K366R, A371V, I375V, A376S, T386I, K390R  
>PW_56| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKISRVGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRSQHPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGAKALTDIVTLTEEAE
LELAENREILKDPVHGVYYDPSKDLVVEIQKQGQDQWTYQIYQEPFKNLKTGKYGRKGSA
HTNDVRQLTEVVQKVSTESIVIWGKIPKFRLPIQKETWEA

References
Author Title Citation
Weidle, PJ Resistance to antiretroviral therapy among patients in Uganda. JAIDS, 2001
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005