Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PW_56 | PW_56 | Uganda | 1999 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC+ SQV | 23 |
| 2 | D4T+ 3TC+ IDV | 38 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L89MV | I13V, K14R, K20I, E35D, M36I, R41K, I62IV, H69K, T74TS |
| >PW_56| codons 1-99 PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVLIEICGKKAIGSVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184MV | V35T, T39K, K49R, I50IV, K122E, D123S, A158S, K173S, N175H, T200A, Q207A, R211S, V245T, A272P, K277R, K281KR, T286A, E291D, V292I, I293V, P294T, E312DG, I326V, A327AV, G335D, A355AG, M357K, R358G, G359S, K366R, A371V, I375V, A376S, T386I, K390R |
| >PW_56| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKISRVGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRSQHPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGAKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLVVEIQKQGQDQWTYQIYQEPFKNLKTGKYGRKGSA HTNDVRQLTEVVQKVSTESIVIWGKIPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Weidle, PJ | Resistance to antiretroviral therapy among patients in Uganda. | JAIDS, 2001 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |