<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PW_UG474 PW_UG474 Uganda 1998 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 None 52

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  V75I     P4T, V35T, T39TA, K49R, I50V, V60I, D121Y, K122E, D123E, K126Q, I132L, I142V, Q174QK, D177E, Q207E, F214L, I244V, V245K, D250E, A272P, T286A, G335D, M357K, G359S, A360V, T377L, T386I, K388KR, K390R, A400T  
>PW_UG474| codons 1-400
PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISRVGPENPYNTPI
FAIKKKDSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
YEEFRQYTAFTLPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPEIVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPVKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSV
HTNDVKQLTEAVQKIALESIVIWGKIPRFRLPIQKETWET

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I13V, M36I, R41K, L63X, I64V  
>PW_UG474| codons 1-99
PQITLWQRPVVTVKIGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIXVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Weidle, PJ Resistance to antiretroviral therapy among patients in Uganda. JAIDS, 2001
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005