Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PW_UG465 | PW_UG465b | Uganda | 1999 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | 3TC+ AZT | 34 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70KR, M184V | N348I | V35T, K49R, V60I, K64KR, K104KN, K122E, D123EK, I135IV, D177E, I178M, G196E, T200A, E203EA, Q207E, R211K, V245K, D250E, L282C, L283I, T286A, I293V, P294AT, E297R, A304E, D324DE, Q334E, G335D, P345Q, F346Y, R356K, M357S, R358RK, A360T, E370A, I375V, T377Q, S379C, K390R, A400T |
| >PW_UG465b| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI FAIRKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIEQHRAKIAELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKCIRGAKALTEVVALTREAE LELEENREILKEPVHGVYYDPSKELIAEIQKQGEDQWTYQIYQEQYKILKTGKYAKSKGT HTNDVKQLTAAVQKVAQECIVIWGKTPKFRLPIQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, I15V, M36I, R41K, L63Q, I64V, I72V |
| >PW_UG465b| codons 1-99 PQITLWQRPLVTVKVGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIQVEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Weidle, PJ | Resistance to antiretroviral therapy among patients in Uganda. | JAIDS, 2001 |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |