<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PW_UG465 PW_UG465b Uganda 1999 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 None 52
2 3TC+ AZT 34

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70KR, M184V N348I     V35T, K49R, V60I, K64KR, K104KN, K122E, D123EK, I135IV, D177E, I178M, G196E, T200A, E203EA, Q207E, R211K, V245K, D250E, L282C, L283I, T286A, I293V, P294AT, E297R, A304E, D324DE, Q334E, G335D, P345Q, F346Y, R356K, M357S, R358RK, A360T, E370A, I375V, T377Q, S379C, K390R, A400T  
>PW_UG465b| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI
FAIRKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYVDDLYVGSDLEIEQHRAKIAELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKCIRGAKALTEVVALTREAE
LELEENREILKEPVHGVYYDPSKELIAEIQKQGEDQWTYQIYQEQYKILKTGKYAKSKGT
HTNDVKQLTAAVQKVAQECIVIWGKTPKFRLPIQKETWET

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, I15V, M36I, R41K, L63Q, I64V, I72V  
>PW_UG465b| codons 1-99
PQITLWQRPLVTVKVGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIQVEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Weidle, PJ Resistance to antiretroviral therapy among patients in Uganda. JAIDS, 2001
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005