Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PW_UG460 | PW_UG460b | Uganda | 1999 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | AZT+ 3TC | 38 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, M184V, T215Y | V35T, S48T, V60I, V90I, K122E, D123S, I135T, S162F, T165I, K173AT, Q174K, D177E, T200A, Q207A, R211S, V245K, D250E, A272P, T286A, E291D, V292VI, I293V, P294T, E312D, G335D, M357R, G359S, T369A, A371V, I375V, T377M, A400T |
| >PW_UG460b| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQFSMIKILEPFRAKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRAHLLSWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRSA HTNDVKQLAEVVQKVAMESIVIWGKTPKFKLPIQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, K14R, G16E, E35D, M36I, R41K, R57K, H69K, L89M |
| >PW_UG460b| codons 1-99 PQITLWQRPIVTVRIEGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |
| Weidle, PJ | Resistance to antiretroviral therapy among patients in Uganda. | JAIDS, 2001 |