Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PW_UG456 | PW_UG456a | Uganda | 1998 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | AZT+ 3TC | 26 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, T39A, K43S, S48ST, V60I, K104KR, D121F, K122E, I142V, K166R, D177E, I178M, T200I, Q207G, R211K, V241X, V245Q, D250E, A272P, K277R, L282C, L283LI, T286X, I293V, I326IM, G335D, P345Q, F346Y, R356K, A360T, T377Q, S379C, T386TA, K390R, A400T |
| >PW_UG456a| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMESEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL FEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRIKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT XQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKCIRGXKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLMAEIQKQGQDQWTYQIYQEQYKNLKTGKYAKMRGT HTNDVKQLTEAVQKIAQECIVIWGKAPKFRLPIQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13IV, I15IV, M36I, R41K, I64V |
| >PW_UG456a| codons 1-99 PQITLWQRPLVTVKVGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |
| Weidle, PJ | Resistance to antiretroviral therapy among patients in Uganda. | JAIDS, 2001 |