Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PW_UG4399 | PW_UG4399a | Uganda | 1998 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | AZT+ 3TC+ RTV | 69 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, K122E, D123N, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, V241I, V245Q, D250E, A272T, V276I, I293V, P294A, E312N, D320E, G335D, M357R, G359S, A360V, A371V, A376V, V381I, A400T |
| >PW_UG4399a| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYVDDLYVGSDLEIGQHRTKIEELRAHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT IQPIQLPEKESWTVNDIQKLVGKLNWASQIYTGIKIKQLCKLLRGTKALTEVVALTEEAE LELAENREILKNPVHGVYYEPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRSV HTNDVKQLTEVVQKIVTESIIIWGKTPKFKLPIQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | L33F | L10V, I13V, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89M |
| >PW_UG4399a| codons 1-99 PQITLWQRPVVTVKIGGQLREALLDTGADDTVFEDINLPGKWKPKMIGGIGGFIKVKQYD QILIEIYGKKAIGTVLVGPTPANIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |
| Weidle, PJ | Resistance to antiretroviral therapy among patients in Uganda. | JAIDS, 2001 |