Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| PW_UG4397 | PW_UG4397a | Uganda | 1999 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | 52 |
| 2 | 3TC+ AZT | 90 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, K70KR, M184V | N348NI | V108VI | E6D, V35T, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, G196GE, T200A, Q207K, R211S, F214FL, T215X, V245K, D250E, K275Q, T286A, E291D, V292VI, I293V, P294T, E312D, Q334PS, G335D, K353KR, M357KQ, G359S, A360AT, T369X, A371AV, I375V, T377K, K390R, A400T |
| >PW_UG4397a| codons 1-400 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYVDDLYVGSDLEIEQHRAKIEELRKHLLSWGLXTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIQVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGPDQWTYQIYQEPFKILKTGRYARKRST HTNDVKQLXEVVQKVAKESIVIWGKTPKFRLPIQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, I15IV, G16GE, E35D, M36I, R41K, I62V, H69K, I72IM, L89M |
| >PW_UG4397a| codons 1-99 PQITLWQRPLVTVKVEGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVLIEICGKKAMGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Non-B Workgroup | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |
| Weidle, PJ | Resistance to antiretroviral therapy among patients in Uganda. | JAIDS, 2001 |