<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
KNH1043 KNH1043 Kenya 1999 HIV1 G PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  V11I I13V, K14R, L19I, K20I, M36I, R41K, C67E, H69K, V82I, L89M  
>KNH1043| codons 1-99
PQITLWQRPLITVRIGGQIIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEIEGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39M, V60I, K122E, D123G, K173T, Q174R, I178M, V189I, T200A, Q207E, R211K, K223R, V245Q, E248D, K275Q, V276T, V292I, I293V, G335D, F346Y, R356K, M357R, R358G, G359S, A376C, T386I, Q394R, A400I, E404D, E413D, Q428R, K431T, V435P, F440Y, V458I, R463K, V467A, S468N, D471E, T477A, H483Q, L491S, K512R, S519N, A534S, A554S  
>KNH1043| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICMEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTRNPDMVI
YQYMDDLYIGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQREPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIQTKQLCKLLRGTKALTEIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPYKNLKTGKYAKRGSA
HTNDVKQLTEAVQKICTESIVIWGKIPKFKLPIRKETWEIWWTDYWQATWIPDWEFVNTP
PLVKLWYRLETEPIPGAETYYVDGAANRETKLGKAGYITDRGKQKVANLTETTNQKAELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNQIIEQLIKKEKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  L68V K14R, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, T206S S283G
>KNH1043| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHVEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Dowling, WE Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. AIDS, 2002