<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
KNH1135 KNH1135 Kenya 1999 HIV1 A PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, K45R, R57K, D60E, L63S, H69K, L89M  
>KNH1135| codons 1-99
PQITLWQRPIVTVKIEGQLREALLDTGADDTVLEDINLSGKWKPRMIGGIGGFIKVKQYE
QISIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39A, S48E, V60I, K122E, D123S, I135T, K173L, Q174K, D177E, V179I, T200A, Q207A, R211S, V245I, D250E, A272P, K275Q, K277R, E291D, V292I, I293V, P294T, E312D, D324E, G335E, M357K, G359S, A360T, K366R, T369A, A371V, I375V, A376V, T377M, K385R, K395R, E399D, A400T, T403M, E404D, E432D, V435E, D471E, Q480H, H483Y, L491S, E514D, S519N, Q524R, K527G, E529D, A534S, A554S, V559I  
>KNH1135| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRLKNPEIII
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIILPEKESWTVNDIQKLVGKLNWASQIYPGIQVRQLCKLLRGTKALTDIVTLTEEAE
LELAENREILKDPVHGVYYDPSKELIAEIQKQGQEQWTYQIYQEPFKNLKTGKYARKRST
HTNDVRQLAEVVQKVVMESIVIWGRTPKFKLPIQRETWDTWWMDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIEGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTETTNQKTELH
AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSDSELVNQIIERLIGKDKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKIL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, A21T, V31I, I72V, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, L234I S283G
>KNH1135| codons 1-288
FLDGIDKAQEEHERYHSNWRTMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Dowling, WE Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. AIDS, 2002