Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| KSM4021 | KSM4021 | Kenya | 1999 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, K20R, E35D, M36I, N37D, R41K, R57K, H69K, L89M |
| >KSM4021| codons 1-99 PQITLWQRPLVTVRIGGQLREALLDTGADDTVLEDIDLPGKWKPKMIGGIGGFIKVKQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K11Q, V35T, T39M, V60I, D121H, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200A, Q207A, F214L, V245M, A272P, T286A, E291D, V292I, I293V, P294T, G335D, M357K, G359A, K366R, T369A, A371V, I375V, A376V, T377M, T386A, K388R, A400T, T403M, E404D, E432D, V435A, S468P, D471E, Q480H, H483F, L491S, K512R, S519N, Q524K, K527E, E529D, K530R, A534S, A554S | V254I |
| >KSM4021| codons 1-560 PISPIETVPVQLKPGMDGPKVKQWPLTEEKIKALTEICMEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYMDDLYVGSDLEIGQHRAKIEELRAHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTINDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRAA HTNDVRQLAEVVQKVVMESIVIWGKAPRFKLPIQKETWETWWMDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTETTNQKTELH AIFLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNQIIEKLIEKDRVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K14R, R20K, M50I, I72V, T112V, I113V, T124A, T125A, K136Q, D167E, K173R, V201I, L234V | S283G |
| >KSM4021| codons 1-288 FLDGIDKAQEEHERYHSNWKAMASDFNLPPVVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLRTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
References
| Author | Title | Citation |
| Dowling, WE | Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. | AIDS, 2002 |