<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
RES081 RES081 South Africa 2011 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP 168
2 3TC+NVP+TDF 47

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, T215F K70Q, V75M V106A F227L K20R, V35T, E36A, T39E, S48T, V60I, K102Q, K122E, I135T, K166R, K173A, D177E, I178L, T200A, Q207E, R211K, D218E, K238R, V245E, A272P, K277R, T286A, E291D, V292I, I293V  
>RES081| codons 1-300
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICEELEKEGKITKIGPENPYNTPI
FAIKKKNSTQWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKQKKSATVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAQNPELVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFFTPEKKHQKEPPLLWMGYELHPDRWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, K14R, L19I, M36I, N37D, R41K, H69K, T74S, L89M, I93L  
>RES081| codons 1-99
PQITLWQRPLVSIRIGGQIKEALLDTGADDTVLEEIDLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Manasa, J High-levels of acquired drug resistance in adult patients failing first-line antiretroviral therapy in a rural HIV treatment programme in KwaZulu-Natal, South Africa. PLoS ONE, 2013