<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 NRTI|NNRTI|PI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, T215F K219Q, N348I     T39TA, V60I, V118I, D123E, I135T, S162A, K173T, Q207A, R211K, V245T, E248V, I293V, D324E, G333E, Q334Y, G359S, T377M, T386TI  
>4108368501| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPITLPVKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQEYGQWTYQIYQEPFKILKTGKYARMRSA
HTNDVKQLTEAVQKIAMESIVIWGKIPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N L10F, L33F, N88D E35D, M36L, N37C, R41K, R57K, D60E, I62V, L63Q, I64V  
>4108368501| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADNTVFEDLCLPGKWKPKMIGGIGGFIKVKQYE
QVQVEICGHKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF

References
Author Title Citation
Margot, NA Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DF. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005