<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 NRTI|NNRTI|PI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y A62AV     T7TS, M16V, K20R, T39TA, K43Q, E44D, R83K, V118I, K122KE, E138A, K166R, G196E, Q207E, H208Y, R211K, Q278H, T286A, T296S, E297K, I329L, Q334QH, G359S, T369V, A376V, T386A  
>2149365661| codons 1-400
PISPIESVPVKLKPGVDGPRVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPV
FVIKKKNSDKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYMDDLYVGSDLEIEQHRTKIEELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVIPLSKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGHGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLVEAVQKIVTESIVIWGKAPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54L, N88S, L90M G73ST L10I, I15V, K20T, E35D, M36I, R41K, K45R, R57K, I62V, L63P, A71T, I72T, I93L  
>2149365661| codons 1-99
PQITLWQRPIVTIKVGGQLTEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFLKVKQYD
QVPIEICGHKTTSTVLVGPTPVNIIGRSLMTQLGCTLNF

References
Author Title Citation
Margot, NA Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DF. AIDS, 2002
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005