Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MM-245836636 | 2458366361 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI|NNRTI|PI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | K103N, Y188L | R83K, K102M, D123E, D177G, H208HY, R211K, V245E, K275R, Q278N, K281R, V292I, I293V, E297K, I329L, G335S, M357T, T386I, K390R |
| >2458366361| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKMNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI YQYMDDLLVGSDLEIGQHRTKIEELRQYLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIRVKNLCRLLRGTKALTEIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQSQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, E35D, R57K, L63P, C67E, H69Y |
| >2458366361| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVKQYD QIPIEIEGYKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Margot, NA | Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DF. | AIDS, 2002 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |