Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 11ZAKS161 | 11ZAKS161 | South Africa | 2011 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+EFV | NA |
| 2 | 3TC+D4T+LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, I62V, L63P, H69K, L89M |
| >11ZAKS161| codons 39-99 PGKWKPKMIGGIGGFIKVRQYDQVPIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLN F |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103N, V106M | F227FL | V35T, T39E, S48T, V60I, K122E, D123G, I135IT, K173A, D177E, T200A, Q207N, V245Q, D250E, A272P, T286A, E291D, V292I, I293V, Q334D, G335D |
| >11ZAKS161| codons 1-345 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSMTVLDVGDAYFSVPL DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRNHLLRWGFTTPDKKHQKEPPLLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEP |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |