Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12ZAKS368 | 12ZAKS368 | South Africa | 2012 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ABC+LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, L63IM, H69K, L89M, I93L |
| >12ZAKS368| codons 39-99 PGKWKPKMIGGIGGFIKVRQYDQIMIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLN F |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K219KN | P4S, V35T, E36A, T39E, S48T, K122E, D123S, I135T, S162SC, T165I, K173A, T200A, Q207E, V245Q, E248A, A272P, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, G359T, T377Q, K385R, K390R, A400T, E404D, E432D |
| >12ZAKS368| codons 1-434 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMIKILEPFRAQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDNKHQKEPPFLWMGYELHPDKWT VQPIQLPAKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIAQESIVIWGRTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKDPI |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |