<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12ZAKS268 12ZAKS268 South Africa 2012 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ABC+EFV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, Y115F, M184V   V106M V179D, F227L K20R, V35T, T39A, S48T, W88C, V90I, K122E, D123N, S162A, K166R, K173A, Q174K, D177E, T200A, Q207E, V245K, A272K, K275Q, T286A, E291D, V292I, I293V, L303M, Q334H, G335D, R356K, G359T, T377I, K390R, A400T, E404D, E413D  
>12ZAKS268| codons 1-434
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFCEIQLGIPHPAGLKKKKSMTVLDVGDAFFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTRILEPFRAKNPEIDI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPLLWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYKGIQVKQLCKLLRGAKALTDIVPLTEEAE
LEMAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKIAIESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPDWEFVNTP
PLVKLWYQLEKEPI

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    R41K, H69K, L89M, I93L  
>12ZAKS268| codons 39-99
PGKWKPKMIGGIGGFIKVRQYDQILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLN
F

References
Author Title Citation
Steegen, K High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. PLoS ONE, 2014