Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12ZAKS282 | 12ZAKS282 | South Africa | 2012 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+LPV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219EQ | K103N | V35T, E36A, T39E, K43Q, V60I, K102KQ, K122E, D123G, K173T, Q174K, D177E, G196E, T200A, E203K, Q207E, V245E, A272P, E291D, V292I, I293V, D324E, Q334N, G335D, R356K, M357R, G359T, A360T, T377Q, K390R, A400I, E404D |
| >12ZAKS282| codons 1-407 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEQEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEIVI YQYVDDLYVGSDLEIEQHRAKIKELREHLLRWGFTTPDQKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKRRTT HTNDVKQLTEAVQKIAQESIVIWGKTPKFRLPIQKETWEIWWTDYWQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47A, V82C | R41K, L63T, H69K, I93L |
| >12ZAKS282| codons 39-99 PGKWKPKMAGGIGGFIKVRQYDQITIEICGKKAIGTVLVGPTPCNIIGRNLLTQLGCTLN F |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |