<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+ABC+LPV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47A, I54V K43T R41K, R57K, D60E, L63P, H69K, A71V, V82I, L89M, I93L  
>12ZAKS291| codons 39-99
PGKWTPKIAGGIGGFVKVKQYEQIPIEICGKKVIGTVLVGPTPINIIGRNMLTQLGCTLN
F

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, M184V       V35T, E36EA, T39E, E40ED, S48T, K122E, D123S, K173T, Q174K, V179I, T200A, Q207K, R211I, F214L, V245I, D250E, A272P, K275Q, K277R, Q278H, T286A, E291D, V292I, I293V, D324E, I329L, Q334N, G335D, R356K, M357R, G359T, V365I, K385R, K390R, A400T, T403S, E404D  
>12ZAKS291| codons 1-420
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEDMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDIII
YQYVDDLYVGSDLEIGQHRAKIEELRKHLLIWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIILPEKESWTVNDIQKLVGKLNWASQIYPGIQVRHLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGNDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDIKQLTEAVQKIATESIVIWGRTPKFRLPIQKETWETWWSDYWQATWIPEWEFVNTP

References
Author Title Citation
Steegen, K High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. PLoS ONE, 2014