Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ABC+LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, H69K, L89M, I93L |
| >12ZAKS313| codons 39-99 PGKWKPKMIGGIGGFIKVRQYDQILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLN F |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V35T, E36A, T39E, S48T, E53D, K122E, D123S, K173R, Q174K, T200A, Q207E, R211S, F214L, V245L, A272P, K277R, T286A, E291D, V292I, I293V, K311R, Q334H, G335D, R356K, G359T, V365I, T377L, K390R, A400T, E404D, K431Q, I434M |
| >12ZAKS313| codons 1-434 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPILLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDIKQLTEAVQKIALESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEQEPM |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |