<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+ABC+EFV NA
2 3TC+D4T+EFV NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, Y115F, M184V   V106M V179E, F227L V35T, T39E, S48T, W88S, K122E, D123N, E138A, K173I, Q174K, D177N, T200A, Q207E, R211K, F214L, V245Q, E248D, A272P, I274IV, K275R, K277R, Q278H, K281KR, T286A, E291D, V292VI, I293V, I329V, G335D, R356K, R358K, G359S, T369TA, A371V, I375V, T377M, K390R, E396D, A400T, E404D  
>12ZAKS203| codons 1-410
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFSEVQLGIPHPAGLKKKKSMTVLDVGDAFFSVPL
DENFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPNIEI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPLLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGVRVRHLCRLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQDQWTYQIYQEPFKNLKTGKYAKMKSA
HTNDVKQLAEVVQKVAMESIVIWGKTPKFRLPIQKDTWETWWTDYWQATW

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  N88D R41K, D60E, Q61E, I62V, L63T, E65D, H69K, L89M, I93L  
>12ZAKS203| codons 39-99
PGKWKPKMIGGIGGFIKVRQYEEVTIDICGKKAIGTVLVGPTPVNIIGRDMLTQLGCTLN
F

References
Author Title Citation
Steegen, K High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. PLoS ONE, 2014