Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, D60E, Q61E, I62V, L63P, H69K, I72M, V77I, L89M, I93L |
| >11ZAKS143| codons 39-99 PGKWKPKMIGGIGGFIKVRQYEEVPIEICGKKAMGTVLIGPTPVNIIGRNMLTQLGCTLN F |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | V21I, K32KR, V35T, E36A, T39E, E40D, S48T, K122E, D123S, E138A, K173I, Q174K, T200A, Q207DE, R211RK, V245Q, E248DN, A272P, K277R, T286A, E291D, V292I, I293V, P313Q |
| >11ZAKS143| codons 1-331 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIRALTAICEDMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPNKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEQVHGVYYDPSKDLIAEIQK |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |