Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ABC+LPV | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| R41K, D60E, Q61E, H69K, V82I, L89M, I93L |
| >11ZAKS144| codons 39-99 PGKWKPKMIGGIGGFIKVRQYEEILIEICGKKAIGTVLVGPTPINIIGRNMLTQLGCTLN F |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | K103N, Y181C | P4H, V35T, E36A, T39D, K122E, D123N, I135T, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272AS, K277R, T286A, E291D, V292I, I293V, E297A, E312EQ |
| >11ZAKS144| codons 1-333 PISHIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICDEMEKEGKISKIGPENPYNTPV FAIKRKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGAKALTDIVPLTAEAE LELAENREILKQPVHGVYYDPSKDLIAEIQKQG |
References
| Author | Title | Citation |
| Steegen, K | High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. | PLoS ONE, 2014 |